I can only honestly say anything about scripters, as the last real botters I know of stopped performing that botting in the early 2000'ies. Both were Calians, one happens to be a RL friend of mine who saved my life and the other is a very cool guy as well. One is hardly playing anymore, the other came back for a while.
I am also of the firm stance that I don't give a flying f*ck about a (or a few) KS, as long you're a normal person(ality) and you don't steal an essential item I was looking for in the process.
Other than that my perception is this:
1. positive: scripters improve the odds that if I get a good item/imbue I won't use myself, they will spend the money on AH to buy it - economy; especially important for people struggling with their cash flow at lower levels
example: I have been anonymously selling items on AH I knew Irk would pay hundreds of PC for and he didn't mind that
2. positive: scripters improve the odds I get my hands on good items I can use if I befriend them
example: love the goodies Laurel receives from her friends!
3. negative: scripters decrease the odds I get my hands on good items I can use if they dislike me
example:
The study of the Calian Council. This is a smallish room where the Council can
read its guidelines as set by Caliana, but it's also somewhere to come for a
bit of peace and quiet from the busy world of Genesis. A small oak reading
table and a comfortable chair are the only furniture in the room, which is lit
by the gentle light of candles.
There is one obvious exit: north.
A weather-worn leather backpack (open), two unusual steel swords, an unusual
broad-bladed steel axe, a peculiar heavy shirt of iron chainmail, an unusual
pair of massive iron bracers, an unusual pair of leather boots, a peculiar pair
of steel greaves, an unusual jeweled breastplate, an unusual red silk sash, an
unusual warm fur, an unusual pair of heavy iron bracers, an unusual bronze-
banded white helmet, an unusual black chainmail, a large backpack, a tempered
spear, two foul stygion-black swords, two sledgehammers of the colossus, a
sword of Mergula, eight iridescent rainbow-hued feathers, five glimmering acid-
etched blades, a humming fire battle-axe, a heavy frost club, a gleaming black
cloak and a council guide book sitting on the reading desk.
A friendly young male human wizard and Maxyz.
4. positive: scripters increase my exp per hour per my effort, if I befriend them
example for me: Irk
5. negative: scripters decrease my exp per hour per effort if they dislike me
example for me: BDA, Calians, ogres
6. positive: scripters get more imbues on the market by working on respewning whole areas
example: Straag
7. negative: imbue/head (ogres) scripters drastically screw up exp per hour per effort for lowbies
example: Kretan camp, Dephonian temple, orc camp in Shire, orcs in Sparkle
8. negative: herb scripters decrease the chances manual herbers achieve their own goals
example: skunk berries
Summary:
1 and 6 are all positive for me - get the AH working, get the cash flowing, get the interactions, get RMC pres Irk to approach sellers directly to bypass AH charges, etc.
2/3 and 4/5 are a balance of gameplay. The easiest way would be to just cancel them out, but that wouldn't fit the reality after all. You are free to choose a total asocial prick as RP and you will end up 3+5, or be the friend of all and everybody ending up 2+4. I think this is a personal choice, but being an asocial prick in RL doesn't get you much aid from others as well.
7 is an issue towards lowbies - I sure agree with that. Maybe closing out lowbie areas for biggies is a global solution that could be implemented, with the shiny steel amulet as means to help your lowbie friends with your main biggie char if needed. Similar to the hive in Terel where you shrink to fit. Or instancing grind areas at all - it was suggested somewhere already.
8 is a nuisance I experienced quite often to be honest. Luckily there are still herbalists out there, but reading about some people having stacks of hundreds of healing herbs makes me throw up. It's bad. On the other hand, they didn't get the exp per hour herbing that I got killing ... trade off.
Having said that, let me pull in griefing into the equation.
The biggest griefers I learned in Gen were not accused of botting or even scripting. Not until Seren, Castaneda, Maxyz, Bast and Alisa decided to join the Irk love parade - and I don't accuse any of those of botting neither. Scripting their asses off - HELL YEAH! Irk is a smallfry scripter compared to some of the best exp per hour grinders in this game (I've been on quite a few exp-trains over the years).